Affiliation:
1. Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305-5402.
Abstract
Transmissible murine colonic hyperplasia is characterized by proliferation of anchored stem cells in the mucosa of the descending colon of laboratory mice and is caused by Citrobacter freundii biotype 4280. This bacterium produces attaching and effacing lesions in the descending colon prior to the onset of gross hyperplasia. By mutational analysis, the chromosomal eae gene of C. freundii biotype 4280 was shown to be necessary for colonic colonization. Conversely, bacteria cured of a 65-kb plasmid, which was identified in C. freundii biotype 4280, were not attenuated for colonic colonization or for the induction of colonic hyperplasia.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference42 articles.
1. Sharing of virulence-associated properties at the phenotypic and genetic levels between enteropathogenic Escherichia coli and Hafnia alvei;Albert M. J.;J. Med. Microbiol.,1992
2. Localization of a determinant for HEp-2 adherence by enteropathogenic Escherichia coli;Baldini M. M.;Infect. Immun.,1986
3. Autoradiographic cytokinetics of colonic mucosal hyperplasia in mice;Barthold S. W.;Cancer Res.,1979
4. The etiology of transmissible murine colonic hyperplasia;Barthold S. W.;Lab. Anim. Sci.,1976
5. Transmissible murine colonic hyperplasia;Barthold S. W.;Vet. Pathol.,1978
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