Increasing Azithromycin Resistance in Neisseria gonorrhoeae Due to NG-MAST 12302 Clonal Spread in Canada, 2015 to 2018-Reference-Cited by-同舟云学术

Increasing Azithromycin Resistance in Neisseria gonorrhoeae Due to NG-MAST 12302 Clonal Spread in Canada, 2015 to 2018

Published:2022-03-15 Issue:3 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sawatzky Pam¹,Demczuk Walter¹^ORCID,Lefebvre Brigitte²,Allen Vanessa³,Diggle Mathew⁴,Hoang Linda⁵,Van Caeseele Paul⁶,Haldane David⁷,Minion Jessica⁸,Mulvey Michael R.¹,Martin Irene¹^ORCID

Affiliation:

1. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

2. Laboratoire de Santé Publique du Québec, Québec City, Quebec, Canada

3. Public Health Ontario Laboratories, Toronto, Ontario, Canada

4. Provincial Laboratory for Public Health, Edmonton, Alberta, Canada

5. British Columbia Centres for Disease Control Public Health Microbiology & Reference Laboratory, Vancouver, British Columbia, Canada

6. Cadham Provincial Laboratory, Winnipeg, Manitoba, Canada

7. Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada

8. Roy Romanow Provincial Laboratory, Regina, Saskatchewan, Canada

Abstract

Azithromycin-resistant (AZIR) gonorrhea has been steadily increasing in Canada over the past decade, which is cause for alarm, as azithromycin (AZI) has been part of the combination therapy recommended by the Canadian Guidelines on Sexually Transmitted Infections (CGSTI) since 2012. Neisseria gonorrhoeae with AZI MICs ≥1 mg/L collected between 2015 and 2018 as part of the Gonococcal Antimicrobial Surveillance Program-Canada underwent antimicrobial susceptibility testing, molecular typing, and whole-genome sequencing. Regional, demographic, and clinical isolation site comparisons were made to aid in our understanding of AZI susceptibility trending.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01688-21

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