A monoclonal antibody to Candida albicans enhances mouse neutrophil candidacidal activity-Reference-Cited by-同舟云学术

A monoclonal antibody to Candida albicans enhances mouse neutrophil candidacidal activity

Published:1997-12 Issue:12 Volume:65 Page:5354-5357
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Caesar-TonThat T C¹,Cutler J E¹

Affiliation:

1. Department of Microbiology, Montana State University, Bozeman 59717-3520, USA.

Abstract

A monoclonal antibody (MAb) to Candida albicans (MAb B6.1) that protects against candidiasis and the nonprotective MAb B6 were compared for ability to support neutrophil (polymorphonuclear leukocyte [PMN]) candidacidal activity. Both MAbs are immunoglobulin M, and each recognizes distinct C. albicans mannan cell wall determinants. PMN candidacidal activity was assessed by transmission electron microscopy and by an in vitro killing assay. The results indicated that MAb B6.1, but not MAb B6, enhances ingestion and killing of yeast cells by PMN in the presence of serum complement.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.65.12.5354-5357.1997

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