Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults-Reference-Cited by-同舟云学术

Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults

Published:1997-11 Issue:11 Volume:65 Page:4873-4876
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Nguer C M¹,Diallo T O¹,Diouf A¹,Tall A¹,Dieye A¹,Perraut R¹,Garraud O¹

Affiliation:

1. Laboratoire d'Immunologie, Institut Pasteur, Dakar, Sénégal.

Abstract

This study shows markedly different isotype distributions of antibodies to asexual blood stages of Plasmodium falciparum and to merozoite surface protein 1 in clinically immune Senegalese adults depending on the study site. The relationships between immunoglobulin M (IgM) and IgG and between IgG3 and IgG1 antibodies differed in settings where transmission is perennial compared to settings where it is seasonal. This suggests a role for antibody class and/or subclass production and utilization in the regulation of protective immunity to such antigens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.65.11.4873-4876.1997

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