Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice-Reference-Cited by-同舟云学术

Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice

Published:1997-10 Issue:10 Volume:65 Page:4334-4336
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Anguita J¹,Samanta S¹,Barthold S W¹,Fikrig E¹

Affiliation:

1. Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA.

Abstract

The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an exacerbation of joint inflammation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.65.10.4334-4336.1997

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