Acquisition of Flucytosine, Azole, and Caspofungin Resistance in Candida glabrata Bloodstream Isolates Serially Obtained from a Hematopoietic Stem Cell Transplant Recipient-Reference-Cited by-同舟云学术

Acquisition of Flucytosine, Azole, and Caspofungin Resistance in Candida glabrata Bloodstream Isolates Serially Obtained from a Hematopoietic Stem Cell Transplant Recipient

Published:2010-03 Issue:3 Volume:54 Page:1360-1362
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chapeland-Leclerc Florence¹,Hennequin Christophe²,Papon Nicolas³,Noël Thierry⁴,Girard Aurélie²,Socié Gérard⁵,Ribaud Patricia⁵,Lacroix Claire⁶

Affiliation:

1. EA 209-Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance, Université Paris Descartes

2. APHP, Hôpital St. Antoine Paris, Laboratoire de Parasitologie-Mycologie, Paris, France

3. EA 2106-Biomolécules et Biotechnologies Végétales, Faculté des Sciences Pharmaceutiques, Université François Rabelais, Tours, France

4. UMR 5234, CNRS Université Bordeaux 2, Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, Bordeaux, France

5. APHP, Hôpital St. Louis Paris, Service d'Hématologie Greffe de Moelle

6. Laboratoire de Mycologie-Parasitologie, Paris, France

Abstract

ABSTRACT We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C. glabrata FUR1 ( CgFUR1 ) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01138-09

Reference20 articles.

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