Advantage of the F2:A1:B- IncF Pandemic Plasmid over IncC Plasmids in In Vitro Acquisition and Evolution of bla CTX-M Gene-Bearing Plasmids in Escherichia coli-Reference-Cited by-同舟云学术

Advantage of the F2:A1:B- IncF Pandemic Plasmid over IncC Plasmids in In Vitro Acquisition and Evolution of bla CTX-M Gene-Bearing Plasmids in Escherichia coli

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mahérault Anne-Claire¹²,Kemble Harry¹,Magnan Mélanie¹,Gachet Benoit¹,Roche David³,Le Nagard Hervé¹,Tenaillon Olivier¹,Denamur Erick¹⁴,Branger Catherine¹,Landraud Luce¹²

Affiliation:

1. Université de Paris, IAME, UMR 1137, INSERM, Paris, France

2. AP-HP, Laboratoire de Microbiologie Hygiène, Hôpital Louis Mourier, Colombes, France

3. Laboratoire d’Analyse Bioinformatique en Génomique et Métabolisme, Institut de Génomique, Commissariat à l’Energie Atomique, Génoscope, CNRS-UMR 8030, Evry, France

4. AP-HP, Laboratoire de Génétique Moléculaire, Hôpital Bichat, Paris, France

Abstract

Despite a fitness cost imposed on bacterial hosts, large conjugative plasmids play a key role in the diffusion of resistance determinants, such as CTX-M extended-spectrum β-lactamases. Among the large conjugative plasmids, IncF plasmids are the most predominant group, and an F2:A1:B- IncF-type plasmid encoding a CTX-M-15 variant was recently described as being strongly associated with the emerging worldwide Escherichia coli sequence type 131 (ST131)-O25b:H4 H 30Rx/C2 sublineage.

Funder

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01130-19

Reference73 articles.

1. World Health Organization. 2014. Antimicrobial resistance: global report on surveillance. World Health Organization, Geneva, Switzerland.

2. Growing Group of Extended-Spectrum β-Lactamases: the CTX-M Enzymes