Zygomycetes Hyphae Trigger an Early, Robust Proinflammatory Response in Human Polymorphonuclear Neutrophils through Toll-Like Receptor 2 Induction but Display Relative Resistance to Oxidative Damage-Reference-Cited by-同舟云学术

Zygomycetes Hyphae Trigger an Early, Robust Proinflammatory Response in Human Polymorphonuclear Neutrophils through Toll-Like Receptor 2 Induction but Display Relative Resistance to Oxidative Damage

Published:2008-02 Issue:2 Volume:52 Page:722-724
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chamilos G.¹,Lewis R. E.¹²,Lamaris G.¹,Walsh T. J.³,Kontoyiannis D. P.¹²

Affiliation:

1. Departments of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, Texas

2. University of Houston College of Pharmacy, Houston, Texas

3. Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland

Abstract

ABSTRACT Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O 2 − release following exposure to Rhizopus oryzae versus that with Aspergillus fumigatus . Exposure of HPMNs to R. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF-κB pathway-related genes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01136-07

Reference14 articles.

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