Affiliation:
1. Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy
Abstract
ABSTRACT
The antimicrobial activity of human β-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of
Staphylococcus aureus
,
Enterococcus faecium
,
Pseudomonas aeruginosa
,
Stenotrophomonas maltophilia
, and
Acinetobacter baumannii
was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
99 articles.
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