Effect of Ribavirin and Glucocorticoid Treatment in a Mouse Model of Human Metapneumovirus Infection-Reference-Cited by-同舟云学术

Effect of Ribavirin and Glucocorticoid Treatment in a Mouse Model of Human Metapneumovirus Infection

Published:2006-02 Issue:2 Volume:50 Page:774-777
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hamelin Marie-Ève¹²,Prince Gregory A.³,Boivin Guy¹²

Affiliation:

1. Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Québec, Sainte-Foy, Québec, Canada;

2. Laval University, Québec City, Québec, Canada

3. Virion Systems, Inc., Rockville, Maryland

Abstract

ABSTRACT Human metapneumovirus (hMPV)-infected BALB/c mice were treated with ribavirin (40 mg/kg of body weight twice a day intraperitoneally), corticosterone (0.2 mg/ml in water), or both modalities. Ribavirin significantly decreased both hMPV replication in lungs (by 5 log 10 ) and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation, compared to controls.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.2.774-777.2006

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