Affiliation:
1. Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA
Abstract
Antibiotic efflux pumps are best known for increasing antibiotic resistance of pathogens; however, the role of these pumps in saprophytes is much less well defined. This study describes two predicted efflux pump gene clusters in the
Chromobacterium
genus, which is comprised of both nonpathogenic saprophytes and species that cause highly fatal human infections. One of the predicted efflux pump clusters is present in every member of the
Chromobacterium
genus and increases resistance to a broad range of antibiotics. The other gene cluster has more narrow antibiotic specificity and is found only in
Chromobacterium subtsugae
, a subset of entirely nonpathogenic species. We demonstrate the role of both pumps in increasing antibiotic resistance and demonstrate the importance of efflux-dependent resistance induction for
C. subtsugae
survival in a dual-species competition model. These results have implications for managing antibiotic-resistant
Chromobacterium
infections and for understanding the evolution of efflux pumps outside the host.
Funder
HHS | National Institutes of Health
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Cited by
14 articles.
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