Affiliation:
1. Department of Chemistry, Arizona State University, Tempe, Arizona
Abstract
Aronson, John
N. (Arizona State University, Tempe),
and Gerald R. Wermus
. Effects of
m
-tyrosine on growth and sporulation of
Bacillus
species. J. Bacteriol.
90:
38–46. 1965.—The aromatic amino acid analogue,
dl
-β-(3-hydroxyphenyl)alanine (
m
-tyrosine), reduced sporulation of a strain of
Bacillus subtilis
to less than 5% of that of control cultures in a glucose-salts minimal medium. The mass-doubling time increased twofold, but maximal growth equivalent to that of control cultures was eventually attained. A decreased growth rate could be maintained in the presence of the analogue for more than 10 doublings, despite incorporation of
m
-tyrosine-
2-C
14
in place of some of the protein phenylalanine. The organism proliferated to chain lengths of 10 to 15 cells. These cells persisted for many hours after maximal growth had been reached, in contrast to normal cultures which had begun to autolyze and sporulate. The response to
m
-tyrosine of strains of
B. cereus, B. thuringiensis
, and
B. megaterium
was like that of
B. subtilis
. In addition,
B. thuringiensis
and
B. cereus
converted
m
-tyrosine to dihydroxyphenylalanine, which was further oxidized to a melaninlike substance. Growth of a strain of
B. stearothermophilus
was not slowed by
m
-tyrosine, but a strain of
Escherichia coli
grew at a reduced rate.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献