How the PhoP/PhoQ System Controls Virulence and Mg 2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution-Reference-Cited by-同舟云学术

How the PhoP/PhoQ System Controls Virulence and Mg 2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution

Published:2021-08-18 Issue:3 Volume:85 Page:
ISSN:1092-2172
Container-title:Microbiology and Molecular Biology Reviews
language:en
Short-container-title:Microbiol Mol Biol Rev

Author:

Groisman Eduardo A.¹²^ORCID,Duprey Alexandre¹^ORCID,Choi Jeongjoon¹^ORCID

Affiliation:

1. Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA

2. Yale Microbial Sciences Institute, West Haven, Connecticut, USA

Abstract

The PhoP/PhoQ two-component system governs virulence, Mg 2+ homeostasis, and resistance to a variety of antimicrobial agents, including acidic pH and cationic antimicrobial peptides, in several Gram-negative bacterial species. Best understood in Salmonella enterica serovar Typhimurium, the PhoP/PhoQ system consists of the sensor PhoQ and the transcriptional regulator PhoP.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

Link

https://journals.asm.org/doi/pdf/10.1128/MMBR.00176-20

Reference419 articles.

1. Characterization of the Catalytic Activities of the PhoQ Histidine Protein Kinase of Salmonella enterica Serovar Typhimurium

2. Functional reconstitution of the Salmonella typhimurium PhoQ histidine kinase sensor in proteoliposomes

3. Intrinsic Negative Feedback Governs Activation Surge in Two-Component Regulatory Systems