Theiler's Virus L* Protein Is Targeted to the Mitochondrial Outer Membrane-Reference-Cited by-同舟云学术

Theiler's Virus L* Protein Is Targeted to the Mitochondrial Outer Membrane

Published:2011-04 Issue:7 Volume:85 Page:3690-3694
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sorgeloos Frédéric¹,Vertommen Didier²,Rider Mark H.²,Michiels Thomas¹

Affiliation:

1. Université Catholique de Louvain, de Duve Institute, MIPA-VIRO 74-49, 74 Avenue Hippocrate, B-1200 Brussels, Belgium

2. Université Catholique de Louvain, de Duve Institute, HORM-PHOS 75-29, 75 Avenue Hippocrate, B-1200 Brussels, Belgium

Abstract

ABSTRACT The L* protein encoded by Theiler's murine encephalomyelitis virus (TMEV) is a unique example of a picornaviral protein encoded by an alternative open reading frame. This protein is an important determinant of TMEV persistence in the mouse central nervous system. We showed that in infected cells, L* is partitioned between the cytosol and the mitochondria. In mitochondria, L* is anchored in the outer membrane and exposed to the cytosol. The targeting of L* to mitochondria is independent of other viral components and likely depends on a conformational signal. L* targeting to mitochondria might involve chaperones of the Hsp70 family, as these proteins are shown to interact.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02023-10

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