Structure of the Spring Viraemia of Carp Virus Ribonucleoprotein Complex Reveals Its Assembly Mechanism and Application in Antiviral Drug Screening

Author:

Wang Zhao-Xi1,Liu Bing2,Yang Tian3,Yu Daqi3,Zhang Chu1,Zheng Liming4,Xie Jin2,Liu Bin1,Liu Mengxi5,Peng Hailin4,Lai Luhua24ORCID,Ouyang Qi23,Ouyang Songying5ORCID,Zhang Yong-An1ORCID

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries, Huazhong Agricultural University, Wuhan, China

2. Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

3. School of Physics, Peking University, Beijing, China

4. College of Chemistry and Molecular Engineering, Peking University, Beijing, China

5. The Key Laboratory of Innate Immune Biology of Fujian Province, Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Biomedical Research Center of South China, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China

Abstract

Aquaculture accounts for about 70% of global aquatic products, and viral diseases severely harm the development of aquaculture industry. Spring viremia of carp virus (SVCV) is the pathogen causing highly contagious spring viremia of carp (SVC) disease in cyprinids, especially common carp ( Cyprinus carpio ), yet neither a vaccine nor effective therapies are available to treat this disease.

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

China Postdoctoral Science Foundation

Special Funds of the Central Government Guiding Local Science and Technology Development

Fujian Normal University

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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