Abstract
Presence of pili of fimbriae on Escherichia coli bacteria isolated from the urine of patients with urinary tract infection was related to the ability of the bacteria to attach to human uroepithelial cells. Piliated E. coli strains agglutinated guinea pig erythrocytes. D-Mannose and alpha-methyl-D-mannopyranoside inhibited this agglutination with all but one of the 12 strains tested. D-Mannose, D-galactose, alpha-methyl-D-mannopyranoside, and L-fucose did not afect attachment of piliated strains to uroepithelial cells. Heating as well as washing of piliated strains caused a parallel decrease of piliation and adhesive ability. Growth in glucose-enriched medium increased capsule formation but decreased piliation and adhesion. Capsulated strains retained their adhesive ability provided that pili extended outside the capsule.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference33 articles.
1. Armitage P. 1973. Statistical methods in medical research p. 398. Blackwell Scientific Publications Oxford.
2. The structure, function, synthesis and genetic control of bacterial pili and a molecular model for DNA and RNA transport in gram negative bacteria;Brinton C. C.;Trans. N. Y. Acad. Sci.,1965
3. Pili as a mediator of the attachment of gonococci to human erythrocytes;Buchanan T. M.;Infect. Immun.,1976
4. Cowan S. T. and K. I. Steel. 1966. Manual for the identification of medical bacteria p. 99. University Press Cambridge.
5. Terminology of bacterial fimbriae, or pili, and their types;Duguid I. P.;Nature (London),1967
Cited by
192 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献