Cerebrospinal Fluid Penetration of Ceftolozane-Tazobactam in Critically Ill Patients with an Indwelling External Ventricular Drain-Reference-Cited by-同舟云学术

Cerebrospinal Fluid Penetration of Ceftolozane-Tazobactam in Critically Ill Patients with an Indwelling External Ventricular Drain

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sime Fekade B.¹²^ORCID,Lassig-Smith Melissa³,Starr Therese³,Stuart Janine³,Pandey Saurabh¹,Parker Suzanne L.¹,Wallis Steven C.¹,Lipman Jeffrey¹³⁴,Roberts Jason A.¹²³⁴⁵^ORCID

Affiliation:

1. University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia

2. School of Pharmacy, Centre for Translational Anti-Infective Pharmacodynamics, The University of Queensland, Brisbane, Australia

3. Department of Intensive Care Medicine, Royal Brisbane and Women’s Hospital, Brisbane, Australia

4. Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France

5. Pharmacy Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia

Abstract

The aim of this study was to describe the pharmacokinetics of ceftolozane-tazobactam in plasma and cerebrospinal fluid (CSF) of infected critically ill patients. In a prospective observational study, critically ill patients (≥18 years) with an indwelling external ventricular drain received a single intravenous dose of 3.0 g ceftolozane-tazobactam. Serial plasma and CSF samples were collected for measurement of unbound ceftolozane and tazobactam concentration by liquid chromatography.

Funder

Merck & Co., Inc. | Merck Sharp and Dohme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01698-20

Reference23 articles.

1. Friedman ND Sexton DJ. 2020. Gram-negative bacillary meningitis: epidemiology clinical features and diagnosis. https://www.uptodate.com/contents/gram-negative-bacillary-meningitis-epidemiology-clinical-features-and-diagnosis#H214635695. Accessed 20 July 2020.

2. Third-generation cephalosporin resistance among Gram-negative bacilli causing meningitis in neurosurgical patients: significant challenges in ensuring effective antibiotic therapy

3. 2017 Infectious Diseases Society of America’s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis*

4. Ceftolozane-Tazobactam for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infections: A Multicenter Study

5. Ceftolozane-Tazobactam for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infections: Clinical Effectiveness and Evolution of Resistance

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Treatment of infections caused by multidrug-resistant Gram-negative bacilli: A practical approach by the Italian (SIMIT) and French (SPILF) Societies of Infectious Diseases;International Journal of Antimicrobial Agents;2024-07

2. What are the optimal pharmacokinetic/pharmacodynamic targets for β-lactamase inhibitors? A systematic review;Journal of Antimicrobial Chemotherapy;2024-03-09

3. New Antibiotics for the Treatment of Nosocomial Central Nervous System Infections;Antibiotics;2024-01-07

4. Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis;Journal of Antimicrobial Chemotherapy;2023-12-28

5. Covariates in population pharmacokinetic studies of critically ill adults receiving β-lactam antimicrobials: a systematic review and narrative synthesis;JAC-Antimicrobial Resistance;2023-12-28