Affiliation:
1. Analytical Research and Methods Development, Quality Control, Pfizer Inc., Groton, Connecticut 06340
Abstract
A quantitative turbidimetric bioassay has been developed for carbenicillin with the use of a strain of
Escherichia coli
. The assay is relatively specific for carbenicillin and is not affected by 10% (wt/wt) benzylpenicillin. It has been demonstrated to be more precise than the plate diffusion assay. Since it is readily automated, it is also faster and less expensive. The influence of pH, time, and extent of growth on the assay has been evaluated.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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