Author:
Spruance S L,Green J A,Chiu G,Yeh T J,Wenerstrom G,Overall J C
Abstract
Of 51 patients with herpes simplex labialis, 50 had detectable interferon (IFN) in samples of lesion vesicle fluid. The median titer of vesicle fluid IFN was 8,200 U. and the range of values was 400 to 63,600 U. The amount of vesicle fluid IFN was correlated with lesion age (r = 0.32, P = 0.024) and vesicle fluid virus titer (r = 0.59, P = 0.00004), but not with the clinical severity of the disease. The presence of vesicle fluid IFN (1,500 to 28,600 U) in 15 lesions less than 12 h old emphasizes the need for early treatment in studies of antiviral agents for herpes simplex labialis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference14 articles.
1. Colton T. 1974. Statistics in medicine. Little Brown & Co. Boston.
2. Rapid, quantitative, semiautomated assay for virus-induced and immune human interferons;Green J. A.;J. Clin. Microbiol.,1980
3. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of antiinterferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, newcastle disease, and influenza viruses;Gresser I.;J. Exp. Med.,1976
4. Topical ether and herpes simplex labialis;Guinan M. E.;J. Am. Med. Assoc.,1980
5. Herpesvirus hominis infection in newborn mice. 1. An experimental model and therapy with iododeoxyruidine;Kern E. R.;J. Infect. Dis.,1973
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献