MicroRNA 181 Suppresses Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection by Targeting PRRSV Receptor CD163-Reference-Cited by-同舟云学术

MicroRNA 181 Suppresses Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection by Targeting PRRSV Receptor CD163

Published:2013-08 Issue:15 Volume:87 Page:8808-8812
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gao Li¹²³,Guo Xue-kun¹²³,Wang Lianghai¹²³,Zhang Qiong¹²³,Li Ning¹⁴,Chen Xin-xin¹²³,Wang Yongqiang¹⁵,Feng Wen-hai¹²³

Affiliation:

1. State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China

2. Ministry of Agriculture, Key Laboratory of Soil Microbiology, China Agricultural University, Beijing, China

3. Department of Microbiology and Immunology, China Agricultural University, Beijing, China

4. Department of Molecular Biology, College of Biological Sciences, China Agricultural University, Beijing, China

5. Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China

Abstract

ABSTRACT We previously showed that microRNA 181 (miR-181) can inhibit PRRSV replication by directly targeting its genomic RNA. Here, we report that miR-181 can downregulate the PRRSV receptor CD163 in blood monocytes and porcine alveolar macrophages (PAMs) through targeting the 3′ untranslated region (UTR) of CD163 mRNA. Downregulation of CD163 leads to the inhibition of PRRSV entry into PAMs and subsequently suppresses PRRSV infection. Our findings indicate that delivery of miR-181 can be used as antiviral therapy against PRRSV infection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00718-13

Reference23 articles.

1. Nidovirales: Evolving the largest RNA virus genome

2. Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark

3. Novel strategies and approaches to develop the next generation of vaccines against porcine reproductive and respiratory syndrome virus (PRRSV);Huang YW;Virus Res,2010

4. Regulation of Cyclin T1 and HIV-1 Replication by MicroRNAs in Resting CD4+ T Lymphocytes

5. miR-198 Inhibits HIV-1 Gene Expression and Replication in Monocytes and Its Mechanism of Action Appears To Involve Repression of Cyclin T1

Cited by 72 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Intervention strategies targeting virus and host factors against porcine reproductive and respiratory syndrome virus: A systematic review;International Journal of Biological Macromolecules;2024-11

2. Inhibition of porcine reproductive and respiratory syndrome virus replication by rifampicin in vitro;Frontiers in Veterinary Science;2024-07-10

3. Role of microRNAs in host defense against porcine reproductive and respiratory syndrome virus infection: a hidden front line;Frontiers in Immunology;2024-03-25

4. MiR-339-5p inhibits replication of porcine reproductive and respiratory syndrome virus by targeting viral gene regions;Virus Genes;2024-02-18

5. Regulatory Non-Coding RNAs during Porcine Viral Infections: Potential Targets for Antiviral Therapy;Viruses;2024-01-13