In Vitro Activities of LY333328 and Comparative Agents against Nosocomial Gram-Positive Pathogens Collected in a 1997 Global Surveillance Study

Author:

Zeckel Michael L.1,Preston David A.1,Allen Bradley S.1

Affiliation:

1. Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285

Abstract

ABSTRACT The in vitro activity of LY333328 was evaluated for 1,479 nosocomial gram-positive pathogens isolated in 12 countries during 1997. LY333328 MICs at which 90% of the isolates tested were inhibited for Enterococcus faecalis ( n = 351), Enterococcus faecium ( n = 100), Staphylococcus aureus ( n = 593), coagulase-negative Staphylococcus species ( n = 325), and Streptococcus pneumoniae ( n = 110) were 1, 1, 2, 2, and 0.015 μg/ml, respectively. LY333328 demonstrated potent activity against isolates of vancomycin-resistant enterococci, oxacillin-resistant staphylococci, and penicillin-resistant pneumococci.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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