In Vitro Activities of a New Des-Fluoroquinolone, BMS 284756, and Seven Other Antimicrobial Agents against 151 Isolates of Eikenella corrodens

Author:

Goldstein Ellie J. C.1,Citron Diane M.1,Merriam C. Vreni1,Warren Yumi A.1,Tyrrell Kerin L.1,Fernandez Helen1

Affiliation:

1. The R. M. Alden Research Laboratory and UCLA Medical Center, Santa Monica, California 90404

Abstract

ABSTRACT The des-fluoroquinolone BMS 284756 was active in vitro against all 151 clinical strains of Eikenella corrodens at a MIC of ≤0.25 μg/ml and was comparable in activity to moxifloxacin and levofloxacin. The MIC at which 90% of the isolates were inhibited by penicillin G was 2 μg/ml; MICs for 8.6% of the strains (13 of 151) were ≥4 μg/ml, including for two beta-lactamase-producing isolates. Amoxicillin-clavulanate and ampicillin-sulbactam inhibited all strains at a MIC of ≤1 μg/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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1. Bacteremia caused by Eikenella corrodens in a patient with pelvic inflammatory disease;Revista Española de Quimioterapia;2023-03-21

2. Eikenella corrodens infections in human: Reports of six cases and review of literatures;Journal of Clinical Laboratory Analysis;2022-01-12

3. Other Gram-Negative and Gram-Variable Bacilli;Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases;2015

4. Eikenella corrodens in Soft Tissue Abscesses;Infectious Diseases in Clinical Practice;2010-09

5. Other Gram-Negative and Gram-Variable Bacilli;Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases;2010

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