Neutrophil-Airway Epithelial Interactions Result in Increased Epithelial Damage and Viral Clearance during Respiratory Syncytial Virus Infection-Reference-Cited by-同舟云学术

Neutrophil-Airway Epithelial Interactions Result in Increased Epithelial Damage and Viral Clearance during Respiratory Syncytial Virus Infection

Published:2020-06-16 Issue:13 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Deng Yu¹²,Herbert Jenny A.¹,Robinson Elisabeth¹,Ren Luo¹²,Smyth Rosalind L.¹,Smith Claire M.¹^ORCID

Affiliation:

1. Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

2. Department of Respiratory Medical Centre, Chongqing Key Laboratory of Child Infection and Immunity, Children’s Hospital of Chongqing Medical University, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China

Abstract

This study shows that the RSV-infected human airway drives changes in the behavior of human neutrophils, including increasing activation markers and delaying apoptosis, that result in greater airway damage and viral clearance.

Funder

Academy of Medical Sciences

Great Ormond Street Hospital Charity

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02161-19

Reference33 articles.

1. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study