Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1-Reference-Cited by-同舟云学术

Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1

Published:2008-04 Issue:4 Volume:46 Page:1530-1533
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Åkerlund Thomas¹,Persson Ingela¹,Unemo Magnus²,Norén Torbjörn³,Svenungsson Bo⁴,Wullt Marlene⁵,Burman Lars G.¹

Affiliation:

1. Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden

2. Department of Clinical Microbiology

3. Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden

4. Department of Communicable Disease Control and Prevention, Karolinska University Hospital, Stockholm, Sweden

5. Department of Clinical Sciences, Infectious Disease Research Unit, Malmö University Hospital, Lund University, Malmö, Sweden

Abstract

ABSTRACT Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the same tcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type 027 isolates, a feature that should contribute to its survival and spread.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01964-07

Reference37 articles.

1. Effect of Fluoroquinolone Treatment on Growth of and Toxin Production by Epidemic and Nonepidemic Clostridium difficile Strains in the Cecal Contents of Mice

2. Correlation of Disease Severity with Fecal Toxin Levels in Patients with Clostridium difficile -Associated Diarrhea and Distribution of PCR Ribotypes and Toxin Yields In Vitro of Corresponding Isolates

3. Biller, P., B. Shank, L. Lind, M. Brennan, L. Tkatch, G. Killgore, A. Thompson, and L. C. McDonald. 2007. Moxifloxacin therapy as a risk factor for Clostridium difficile-associated disease during an outbreak: attempts to control a new epidemic strain. Infect. Control Hosp. Epidemiol.28:198-201.

4. In Vitro Susceptibility of Clostridium difficile Clinical Isolates from a Multi-Institutional Outbreak in Southern Québec, Canada

5. tcdC Genotypes Associated with Severe TcdC Truncation in an Epidemic Clone and Other Strains of Clostridium difficile

Cited by 187 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. “Primum, non nocere”: The Epidemiology of Toxigenic Clostridioides difficile Strains in the Antibiotic Era—Insights from a Prospective Study at a Regional Infectious Diseases Hospital in Eastern Europe;Antibiotics;2024-05-17

2. Clostridioides difficile Infection: Diagnosis and Treatment Challenges;Pathogens;2024-01-27

3. Clostridioides difficile Sporulation;Advances in Experimental Medicine and Biology;2024

4. Prevalence of toxigenic Clostridium difficile in hospitalized patients in the southwestern province of Saudi Arabia: Confirmation using the GeneXpert analysis;Libyan Journal of Medicine;2023-12-19

5. One size does not fit all – Trehalose metabolism by Clostridioides difficile is variable across the five phylogenetic lineages;Microbial Genomics;2023-09-28