Affiliation:
1. Department of Medical Microbiology, University Hospital Nijmegen, The Netherlands.
Abstract
Sulfadiazine and the metabolites N4-acetyl-sulfadiazine, 4-OH-sulfadiazine, 5-OH-sulfadiazine, 5-OH-glucuronide-sulfadiazine, and 5-OH-sulfate-sulfadiazine were tested separately and in combination with pyrimethamine for the inhibitory activity on Toxoplasma gondii growth in vitro. Except for N4-acetyl-sulfadiazine, all sulfa compounds possessed anti-Toxoplasma activity. The addition of 0.05 micrograms of pyrimethamine per ml, a concentration which in itself is not inhibitory, potentiated the microbial activity of sulfadiazine and its metabolites 100 fold.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference21 articles.
1. A new coupling component for sulfanilamide determination;Bratton A. C.;J. Biol. Chem.,1939
2. In vitro effects of three new 1,2,4-trioxanes (pentatroxane, thiahexatroxane, and hexatroxanone) on Toxoplasma gondii;Chang H. R.;Antimicrob. Agents Chemother.,1989
3. In vitro effects of folate inhibitors on Toxoplasma gondii;Derouin F.;Antimicrob. Agents Chemother.,1989
4. Goodman Gilman A. T. W. Rall A. S. Nies and P. Taylor. 1990. The pharmacological basis of therapeutics 8th ed. p. 985-987 1047-1054. Pergamon Press New York.
5. In vitro assessment of antimicrobial agents against Toxoplasma gondii;Harris C.;J. Infect. Dis.,1988
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献