The Activation of the RIG-I/MDA5 Signaling Pathway upon Influenza D Virus Infection Impairs the Pulmonary Proinflammatory Response Triggered by Mycoplasma bovis Superinfection

Author:

Gaudino Maria1,Lion Adrien1,Sagné Eveline1,Nagamine Brandy1,Oliva Justine23,Terrier Olivier23ORCID,Errazuriz-Cerda Elisabeth4,Scribe Anaëlle1,Sikht Fatima-Zohra1,Simon Elisa1,Foret-Lucas Charlotte1,Gausserès Blandine1,Lion Julie1,Moreno Ana5,Dordet-Frisoni Emilie1,Baranowski Eric1,Volmer Romain1ORCID,Ducatez Mariette F.1,Meyer Gilles1ORCID

Affiliation:

1. IHAP, Université de Toulouse, INRAE, ENVT, Toulouse, France

2. Centre International de Recherche en Infectiologie – U1111 (Equipe VirPath) – Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure, Lyon, France

3. Centre National de la Recherche Scientifique – UMR5308, Lyon, France

4. Centre d’Imagerie Quantitative Lyon 1, Lyon, France

5. Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna “Bruno Ubertini,” Brescia, Italy

Abstract

Since the spread of the respiratory influenza D virus (IDV) infection to the cattle population, the question about the impact of this virus on bovine respiratory disease (BRD) remains still unanswered. Animals affected by BRD are often coinfected with multiple pathogens, especially viruses and bacteria.

Funder

Agence Nationale de la Recherche

Ecole Nationale Veterinaire de Toulouse

Institut National de la Recherche Agronomique

Occitanie Region

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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