Genotypic Resistance Testing of HIV-1 DNA in Peripheral Blood Mononuclear Cells-Reference-Cited by-同舟云学术

Genotypic Resistance Testing of HIV-1 DNA in Peripheral Blood Mononuclear Cells

Published:2022-12-21 Issue:4 Volume:35 Page:
ISSN:0893-8512
Container-title:Clinical Microbiology Reviews
language:en
Short-container-title:Clin Microbiol Rev

Author:

Chu Carolyn¹,Armenia Daniele²,Walworth Charles³,Santoro Maria M.⁴,Shafer Robert W.⁵^ORCID

Affiliation:

1. Department of Family and Community Medicine, University of California San Francisco, San Francisco, California, USA

2. UniCamillus, Saint Camillus International University of Health Sciences, Rome, Italy

3. LabCorp-Monogram Biosciences, South San Francisco, California, USA

4. Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy

5. Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, California, USA

Abstract

HIV-1 DNA exists in nonintegrated linear and circular episomal forms and as integrated proviruses. In patients with plasma viremia, most peripheral blood mononuclear cell (PBMC) HIV-1 DNA consists of recently produced nonintegrated virus DNA while in patients with prolonged virological suppression (VS) on antiretroviral therapy (ART), most PBMC HIV-1 DNA consists of proviral DNA produced months to years earlier.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | Health Resources and Services Administration

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Link

https://journals.asm.org/doi/pdf/10.1128/cmr.00052-22

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2. Antiviral Efficacy of Abacavir in Antiretroviral Therapy-Experienced Adults Harbouring HIV-1 with Specific Patterns of Resistance to Nucleoside Reverse Transcriptase Inhibitors