CRM1 Promotes Capsid Disassembly and Nuclear Envelope Translocation of Adenovirus Independently of Its Export Function

Author:

Lagadec Floriane12,Carlon-Andres Irene2,Ragues Jessica2,Port Sarah1,Wodrich Harald2ORCID,Kehlenbach Ralph H.1ORCID

Affiliation:

1. Department of Molecular Biology, Faculty of Medicine, Göttingen Center of Biosciences (GZMB), Georg-August-University Göttingen, Göttingen, Germany

2. CNRS UMR 5234, Fundamental Microbiology and Pathogenicity, Université de Bordeaux, Bordeaux, France

Abstract

A role of nucleoporins and of soluble transport factors in adenoviral genome import into the nucleus of infected cells in interphase has previously been established. The nuclear export receptor CRM1 promotes genome import, but its precise function is not known.

Funder

Deutsche Forschungsgemeinschaft

Fondation pour la Recherche Médicale

Université de Bordeaux

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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