A Biosafety Level 2 Mouse Model for Studying Betacoronavirus-Induced Acute Lung Damage and Systemic Manifestations-Reference-Cited by-同舟云学术

A Biosafety Level 2 Mouse Model for Studying Betacoronavirus-Induced Acute Lung Damage and Systemic Manifestations

Published:2021-10-27 Issue:22 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Andrade Ana Cláudia dos Santos Pereira¹,Campolina-Silva Gabriel Henrique²,Queiroz-Junior Celso Martins¹,de Oliveira Leonardo Camilo¹,Lacerda Larisse de Souza Barbosa¹,Gaggino Jordane Clarisse Pimenta¹,de Souza Filipe Resende Oliveira¹,de Meira Chaves Ian¹,Passos Ingredy Beatriz³,Teixeira Danielle Cunha¹,Bittencourt-Silva Paloma Graziele⁴,Valadão Priscila Aparecida Costa¹,Rossi-Oliveira Leonardo¹,Antunes Maisa Mota¹,Figueiredo André Felipe Almeida¹,Wnuk Natália Teixeira¹,Temerozo Jairo R.⁵⁶^ORCID,Ferreira André Costa⁷⁸⁹,Cramer Allysson²,Oliveira Cleida Aparecida¹,Durães-Carvalho Ricardo¹⁰^ORCID,Weis Arns Clarice¹⁰,Guimarães Pedro Pires Goulart⁴,Costa Guilherme Mattos Jardim¹,de Menezes Gustavo Batista¹,Guatimosim Cristina¹,da Silva Glauber Santos Ferreira⁴,Souza Thiago Moreno L.⁷⁸,Barrioni Breno Rocha¹¹,Pereira Marivalda de Magalhães¹¹,de Sousa Lirlândia Pires¹²,Teixeira Mauro Martins²,Costa Vivian Vasconcelos¹²^ORCID

Affiliation:

1. Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

2. Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

3. Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

4. Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

5. Laboratory on Thymus Research, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil

6. National Institute for Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil

7. National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDNP), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil

8. Immunopharmacology Laboratory, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil

9. Laboratório de Pesquisas Pré-clínicas, Universidade Iguaçu (UNIG), Rio de Janeiro, RJ, Brazil

10. Laboratory of Virology, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil

11. Department of Metallurgical Engineering and Materials, Federal University of Minas Gerais, School of Engineering, Belo Horizonte, Brazil

12. Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

Abstract

Mouse models have long been used as valuable in vivo platforms to investigate the pathogenesis of viral infections and effective countermeasures. The natural resistance of mice to the novel betacoronavirus SARS-CoV-2, the causative agent of COVID-19, has launched a race toward the characterization of SARS-CoV-2 infection in other animals (e.g., hamsters, cats, ferrets, bats, and monkeys), as well as adaptation of the mouse model, by modifying either the host or the virus.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Ferring Research Institute

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01276-21

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1. Origin and evolution of pathogenic coronaviruses