Porcine Circovirus 2 Activates the PERK-Reactive Oxygen Species Axis To Induce p53 Phosphorylation with Subsequent Cell Cycle Arrest at S Phase in Favor of Its Replication-Reference-Cited by-同舟云学术

Porcine Circovirus 2 Activates the PERK-Reactive Oxygen Species Axis To Induce p53 Phosphorylation with Subsequent Cell Cycle Arrest at S Phase in Favor of Its Replication

Published:2022-11-23 Issue:22 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Deng Zhuofan¹²,Sun Renjie¹²,Han Xiao¹²^ORCID,Zhang Yikai¹²,Zhou Yingshan³,Shan Ying¹²,Xu Jidong¹²,Li Xiaoliang¹²^ORCID,He Fang¹²^ORCID,Fang Weihuan¹²³^ORCID

Affiliation:

1. Zhejiang University, Institute of Preventive Veterinary Medicine, Hangzhou, Zhejiang, China

2. Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Hangzhou, Zhejiang, China

3. Zhejiang A&F University, College of Veterinary Medicine, Hangzhou, Zhejiang, China

Abstract

Coinfections or noninfectious triggers have long been considered to potentiate PCV2 infection, leading to manifestation of PCVAD. The triggering mechanisms remain largely unknown.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01274-22

Reference64 articles.

1. Porcine Circovirus Type 2 and Porcine Circovirus-Associated Disease

2. Porcine circovirus type 2 (PCV2) infections: Clinical signs, pathology and laboratory diagnosis

3. Porcine Circovirus Type 2–Associated Disease: Update on Current Terminology, Clinical Manifestations, Pathogenesis, Diagnosis, and Intervention Strategies

4. Transcriptional Analysis of Porcine Circovirus Type 2

5. Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein

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