Comparative Genomics and Antimicrobial Resistance Profiling of Elizabethkingia Isolates Reveal Nosocomial Transmission and In Vitro Susceptibility to Fluoroquinolones, Tetracyclines, and Trimethoprim-Sulfamethoxazole-Reference-Cited by-同舟云学术

Comparative Genomics and Antimicrobial Resistance Profiling of Elizabethkingia Isolates Reveal Nosocomial Transmission and In Vitro Susceptibility to Fluoroquinolones, Tetracyclines, and Trimethoprim-Sulfamethoxazole

Published:2020-08-24 Issue:9 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Burnard Delaney¹²³,Gore Letitia⁴,Henderson Andrew¹,Ranasinghe Ama¹,Bergh Haakon⁴,Cottrell Kyra¹,Sarovich Derek S.²³^ORCID,Price Erin P.²³^ORCID,Paterson David L.¹,Harris Patrick N. A.¹⁴^ORCID

Affiliation:

1. University of Queensland Centre for Clinical Research, Royal Brisbane and Woman’s Hospital, Herston, Queensland, Australia

2. Genecology Research Centre, University of the Sunshine Coast, Sippy Downs, Queensland, Australia

3. Sunshine Coast Health Institute, Birtinya, Queensland, Australia

4. Central Microbiology, Pathology Queensland, Queensland Health, Herston, Queensland, Australia

Abstract

The Elizabethkingia genus has gained global attention in recent years as containing sporadic, worldwide, nosocomial pathogens. Elizabethkingia spp. are intrinsically multidrug resistant, primarily infect immunocompromised individuals, and are associated with high mortality (∼20 to 40%). As yet, gaps remain in our understanding of transmission, global strain relatedness, antimicrobial resistance, and effective therapy. Over a 16-year period, 22 clinical and 6 hospital environmental isolates were collected from Queensland, Australia.

Funder

SERC Pathology Queensland

Department of Health | National Health and Medical Research Council

State of Queensland | Advance Queensland

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00730-20

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1. WaterborneElizabethkingia meningosepticain Adult Critical Care1