Immunity to Staphylococcal Infection in Mice: Effect of Living Versus Killed Vaccine, Role of Circulating Antibody, and Induction of Protection-Inducing Antigen(s) In Vitro-Reference-Cited by-同舟云学术

Immunity to Staphylococcal Infection in Mice: Effect of Living Versus Killed Vaccine, Role of Circulating Antibody, and Induction of Protection-Inducing Antigen(s) In Vitro

Published:1969-11 Issue:2 Volume:100 Page:745-750
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Ekstedt Richard D.¹,Yoshida Kosaku¹

Affiliation:

1. Department of Microbiology, Northwestern University Medical School, Chicago, Illinois 60611

Abstract

Mice immunized by sublethal doses of living Staphylococcus aureus strains other than the Smith diffuse strain were significantly more resistant to challenge with the Smith diffuse strain than animals immunized with heat-killed organisms. The increased resistance observed was shown, by appropriate passive protection experiments with immune mouse sera, to be due to circulating antibody, probably of the IgM class. In addition, it was observed that strains of S. aureus other than the Smith diffuse strain, when cultured in a modified Staphylococcus 110 broth but not in Brain Heart Infusion, were capable of absorbing protective antibody from hyperimmune rabbit antiserum.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.100.2.745-750.1969

Reference12 articles.

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3. Studies on immunity to staphylococcal infection in mice. II. Effect of immunization with fractions of Staphylococcus aureus prepared by physical and chemical methods;Ekstedt R. D.;J. Infec. Dis.,1963

4. Mechanisms of resistance to staphylococcal infection: natural and acquired;Ekstedt R. D.;Ann. N. Y. Acad. Sci.,1965

5. The virulence of Staphylococcus pyogenes for man. A study of the problems of wound infection;Elek S. D.;Brit. J. Exp. Pathol.,1957

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