Human Herpesvirus 6 Chromosomal Integration in Immunocompetent Patients Results in High Levels of Viral DNA in Blood, Sera, and Hair Follicles-Reference-Cited by-同舟云学术

Human Herpesvirus 6 Chromosomal Integration in Immunocompetent Patients Results in High Levels of Viral DNA in Blood, Sera, and Hair Follicles

Published:2006-04 Issue:4 Volume:44 Page:1571-1574
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Ward Katherine N.¹,Leong Hoe Nam²,Nacheva Elisabeth P.³,Howard Julie³,Atkinson Claire E.²,Davies Nicholas W. S.⁴,Griffiths Paul D.²,Clark Duncan A.²

Affiliation:

1. Division of Infection and Immunity, Centre for Virology, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School (University College London C Campus), 46 Cleveland Street, London W1T 4JF

2. Division of Infection and Immunity, Centre for Virology

3. Department of Haematology, Royal Free and University College Medical School (Hampstead campus), Rowland Hill Street, London NW3 2PF

4. Department of Neurological Intensive Care, The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, United Kingdom

Abstract

ABSTRACT Six immunocompetent patients with human herpesvirus 6 (HHV-6) chromosomal integration had HHV-6 and β-globin DNA quantified in various samples by PCR. The mean HHV-6 DNA concentration (log 10 copies/milliliter) in blood was 7.0 (≥1 HHV-6 DNA copies/leukocyte), and in serum it was 5.3 (≥1 HHV-6 DNA copies/lysed cell). The mean HHV-6 DNA load (log 10 copies)/hair follicle was 4.2 (≥1 copies/hair follicle cell), demonstrating that viral integration is not confined to blood cells. The characteristically high HHV-6 DNA levels in chromosomal integration may confound laboratory diagnosis of HHV-6 infection and should be given due consideration.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.44.4.1571-1574.2006

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