Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections-Reference-Cited by-同舟云学术

Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zelenitsky Sheryl A.¹²^ORCID,Calic Divna¹,Arora Rakesh C.³⁴,Grocott Hilary P.³⁴,Lakowski Ted M.¹⁵,Lillico Ryan¹,Ariano Robert E.¹²

Affiliation:

1. College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

2. Department of Pharmacy, St. Boniface Hospital, Winnipeg, Manitoba, Canada

3. Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

4. Cardiac Sciences Program, St. Boniface Hospital, Winnipeg, Manitoba, Canada

5. Pharmaceutical Analysis Laboratory, College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

Abstract

This study characterizes the pharmacodynamics of antimicrobial prophylaxis and sternal wound infections following cardiac surgery. Duration of surgery and cefazolin plasma concentration during wound closure were independently associated with surgical site infection at 30 days.

Funder

Canadian Society of Hospital Pharmacists Foundation Grant

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01360-18

Reference18 articles.

1. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017

2. World Health Organization. 2016. Global guidelines for the prevention of surgical site infection. World Health Organization Geneva Switzerland. http://www.who.int/gpsc/ssi-prevention-guidelines/en/.

3. Clinical practice guidelines for antimicrobial prophylaxis in surgery

4. The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections

5. Recent Updates on the Role of Pharmacokinetics-pharmacodynamics in Antimicrobial Susceptibility Testing as Applied to Clinical Practice

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