Interferon Induction in Cynomolgus and Rhesus Monkeys After Repeated Doses of a Modified Polyriboinosinic-Polyribocytidylic Acid Complex-Reference-Cited by-同舟云学术

Interferon Induction in Cynomolgus and Rhesus Monkeys After Repeated Doses of a Modified Polyriboinosinic-Polyribocytidylic Acid Complex

Published:1977-01 Issue:1 Volume:11 Page:80-83
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sammons M. L.¹,Stephen E. L.²,Levy H. B.¹,Baron S.¹,Hilmas D. E.¹

Affiliation:

1. National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 21714, University of Texas Medical Branch, Galveston, Texas 77550

2. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701,

Abstract

Serum interferon activity was determined in 12 cynomolgus and 12 rhesus monkeys injected intravenously once daily for 10 days with from 0.1 to 6.0 mg of a stabilized polyriboinosinic acid · polyribocytidylic acid complex per kg, composed of polyriboinosinic acid · polyribocytidylic acid, poly-1-lysine, and carboxymethylcellulose [poly(ICLC)]. Interferon activity was detected 2 h after the first injection, with maximum activity occurring 8 h after the second injection. A period of hyporesponsiveness occurred after the third injection of poly(ICLC) in all monkeys and lasted until the sixth injection in the rhesus monkeys, when interferon activity again became more elevated. The delayed rebound was not as apparent in cynomolgus monkeys. Rhesus monkeys injected with 6 mg/kg did not exhibit serious side effects.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.11.1.80

Reference14 articles.

1. Semi-micro, dye-binding assay for rabbit interferon;Armstrong J. A.;Appl. Microbiol.,1971

2. The interferon refractory state: in vivo and in vitro studies of its mechanism;Borden E. C.;J. Immunol.,1971

3. The interferon refractory state. II. Biological characterization of a refractoriness-inducing protein;Borden E. C.;J. Immunol.,1975

4. Kinetics of serum interferon response in mice after single and multiple injections of polyI-polyC;Buckler C. E.;Proc. Soc. Exp. Biol. Med.,1971

5. Relationship between dose size and dose interval of polyinosinic-polycytidylic acid and interferon responsiveness in mice;DuBuy H. G.;Proc. Soc. Exp. Biol. Med.,1970

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