Roles of TolC-Dependent Multidrug Transporters of Escherichia coli in Resistance to β-Lactams-Reference-Cited by-同舟云学术

Roles of TolC-Dependent Multidrug Transporters of Escherichia coli in Resistance to β-Lactams

Published:2003-09 Issue:9 Volume:47 Page:3030-3033
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nishino Kunihiko¹²³⁴,Yamada Junko¹²³,Hirakawa Hidetada¹²³,Hirata Takahiro¹²³,Yamaguchi Akihito¹²³

Affiliation:

1. Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki

2. CREST, Japan Science and Technology Corporation, Osaka 567-0047

3. Faculty of Pharmaceutical Science

4. Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan

Abstract

ABSTRACT AcrAB exports some β-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC. In this study, the roles of the drug exporters of E. coli in β-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer β-lactam antibiotic resistance, while no other drug exporters confer any β-lactam resistance even when they cooperate with TolC.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.9.3030-3033.2003

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