Real-Time PCR as a Versatile Tool for Investigating the Susceptibility of Human Herpesvirus 6 to Antiviral Agents-Reference-Cited by-同舟云学术

Real-Time PCR as a Versatile Tool for Investigating the Susceptibility of Human Herpesvirus 6 to Antiviral Agents

Published:2003-09 Issue:9 Volume:47 Page:3021-3024
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Macé Muriel¹,Manichanh Chaysavanh¹,Bonnafous Pascale¹,Précigout Stéphanie¹,Boutolleau David¹,Gautheret-Dejean Agnès¹²,Agut Henri¹

Affiliation:

1. Laboratoire de Virologie, UPRES EA2387, CERVI, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris

2. Laboratoire de Microbiologie, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France

Abstract

ABSTRACT A quantitative real-time PCR assay was developed for the determination of antiviral drug susceptibility and growth kinetics of human herpesvirus 6. The susceptibility and fitness of a sensitive strain, HST, and its ganciclovir-resistant derivative, GCVR1, were then characterized, leading us to conclude that the mutations of this latter virus did not alter its fitness significantly.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.9.3021-3024.2003

Reference15 articles.

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