Candida Isolates from Neonates: Frequency of Misidentification and Reduced Fluconazole Susceptibility

Author:

Rowen Judith L.1,Tate Judy M.1,Nordoff Nicole2,Passarell Lester2,McGinnis Michael R.2

Affiliation:

1. Departments of Pediatrics1 and

2. Pathology,2 University of Texas Medical Branch, Galveston, Texas 77555

Abstract

ABSTRACT Systemic candidiasis affects 1.6 to 4.5% of very low birth weight (≤1,500 g) infants. A specimen archive of Candida strains from intensive care nurseries was created; it currently houses 98 isolates from 17 institutions. Eight isolates (8.2%) were misidentified at the referring institution. The MICs of fluconazole for seven isolates (7.1%, all non- C. albicans species, one misidentified initially) were >8 μg/ml.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference22 articles.

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2. Candida: an increasingly important pathogen in the nursery;Butler K. M.;Pediatr. Clin. N. Am.,1988

3. Fluconazole vs. amphotericin B for the treatment of neonatal fungal septicemia: a prospective randomized trial;Driessen M.;Pediatr. Infect. Dis. J.,1996

4. Systemic Candida infections in infants in intensive care nurseries: high incidence of central nervous system involvement;Faix R. G.;J. Pediatr.,1984

5. Mucocutaneous and invasive candidiasis among very low birth weight (<1,500 grams) infants in intensive care nurseries: a prospective study;Faix R. G.;Pediatrics,1989

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