Intravenous Immunoglobulin Therapy: Confounding Effects on Serological Screening for Toxoplasmosis during Pregnancy

Author:

Pelloux Hervé1,Fricker-Hidalgo Hélène1,Brochier Gilbert2,Goullier-Fleuret Andrée1,Ambroise-Thomas Pierre1

Affiliation:

1. Service de Parasitologie-Mycologie, CHU A Michallon, 38043 Grenoble Cedex,1 and

2. Etablissement de Transfusion Sanguine Isère-Savoie, 502 fbg Maché, 73001 Chambéry Cedex,2France

Abstract

ABSTRACT The serological diagnosis of toxoplasmic infection during pregnancy is intended to prevent congenital infection of the fetus. However, in the context of recurrent pregnancy loss intravenous immunoglobulin therapy can create a biological trap for the interpretation of serological results, with potentially serious consequences for the outcome of the pregnancy.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference8 articles.

1. Evaluation of the second generation IMX toxo IgG antibody assay for detection of antibodies to Toxoplasma gondii in human sera;De Champs C.;J. Clin. Lab. Anal.,1997

2. Interférence des immunoglobulines polyvalentes dans la sérologie toxoplasmique;Fortier B.;Ann. Biol. Clin.,1992

3. Prenatal diagnosis of congenital toxoplasmosis with a polymerase-chain-reaction test on amniotic fluid;Hohlfeld P. H.;N. Engl. J. Med.,1994

4. The use of intravenous immunoglobulin in recurrent pregnancy loss associated with combined alloimmune and autoimmune abnormalities;Kiprov D. D.;Am. J. Reprod. Immunol.,1996

5. Spurious serologic test results in patients receiving infusions of intravenous immune gammaglobulin;Lichtiger B.;Arch. Pathol. Lab. Med.,1991

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