Affiliation:
1. Laboratory of Clinical Biochemistry, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014
Abstract
Escherichia coli
K-12, strain AB1172, substrain 2276, a methionine
−
-cyano-B
12
−
auxotroph grew poorly when placed in a medium containing optimal levels of cyano-B
12
and suboptimal amounts of
l
-methionine. A marked depression of
N
5,10
-methylene-H
4
-folate reductase was observed in the inhibited cells, although no significant alterations in other enzymes involved in the metabolism of
N
5,10
-methylene-H
4
-folate were observed. Guanosine was effective in preventing the growth inhibition.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
1 articles.
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