Effects of Oil-treated Mycobacterial Cell Walls on the Organs of Mice

Author:

Barclay William R.1,Anacker Robert1,Brehmer Werner1,Ribi Edgar1

Affiliation:

1. Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840

Abstract

Intravenous vaccination of mice with oil-treated mycobacterial cell walls resulted in a marked macrophage accumulation in the lungs and spleens of vaccinated animals. Injection of oil emulsion alone or of cell walls alone failed to elicit the macrophage response. Although a correlation existed between the magnitude of the macrophage response and the degree of immunity against aerosol challenge with H 37 Rv organisms, the findings presented here do not rule out the possibility that qualitative differences may be present in the macrophages of animals vaccinated against tuberculosis. The ability of oil-treated cell walls to elicit an immune response appeared to be a function of the physical association of cell wall fragments and the surface of oil droplets.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference8 articles.

1. Duration of immunity to tuberculosis in mice vaccinated intravenously with oil-treated cell walls of Mycobacterium bovis strain B.C.G;ANACKER R. L.;J. Immunol.,1967

2. Factors influencing protection against experimental tuberculosis in mice by heat-stable cell wall vaccines;RIBI E., R.;J. Bacteriol.,1966

3. Specificity of resistance to tuberculosis and salmonellosis stimulated in mice by oil-treated cell walls;RIBI E., W.;Proc. Soc. Exptl. Biol. Med.,1967

4. Resistance to experimental tuberculosis stimulated by fractions from attenuated tubercle bacilli;RIBI E., C.;Proc. Soc. Exptl. Biol. Med.,1965

5. Effective nonliving vaccine against experimental tuberculosis in mice;RIBI E., C.;J. Bacteriol.,1966

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