Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017−2018 INFORM-RSV Study-Reference-Cited by-同舟云学术

Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017−2018 INFORM-RSV Study

Published:2020-12-17 Issue:1 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Tabor David E.¹,Fernandes Fiona²,Langedijk Annefleur C.³,Wilkins Deidre¹,Lebbink Robert Jan⁴,Tovchigrechko Andrey⁵,Ruzin Alexey¹,Kragten-Tabatabaie Leyla⁶⁷,Jin Hong²,Esser Mark T.¹,Bont Louis J.³⁶,Abram Michael E.¹^ORCID,

Affiliation:

1. Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA

2. Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, San Francisco, California, USA

3. Department of Paediatrics, Division of Paediatric Infectious Diseases, Wilhelmina Children’s Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands

4. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands

5. Data Sciences & Artificial Intelligence, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA

6. ReSViNET Foundation, Zeist, The Netherlands

7. Julius Clinical, Zeist, The Netherlands

Abstract

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular epidemiology of RSV in children under 5 years of age by monitoring temporal and geographical evolution of current circulating RSV strains, F protein antigenic sites, and their relationships with clinical features of RSV disease. During the pilot season (2017–2018), 410 RSV G-F gene sequences were obtained from 476 RSV-positive nasal samples collected from 8 countries (United Kingdom, Spain, The Netherlands, Finland, Japan, Brazil, South Africa, and Australia).

Funder

AstraZeneca

Sanofi US | Sanofi Pasteur

Julius Clinical

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01828-20

Reference43 articles.

1. The Burden of Respiratory Syncytial Virus Infection in Young Children