Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin-Tazobactam, Cefepime, or Meropenem

Author:

Blevins Adam M.1,Lashinsky Jennifer N.2,McCammon Craig2,Kollef Marin3,Micek Scott24,Juang Paul24

Affiliation:

1. Department of Pharmacy, The University of Kansas Health System, Kansas City, Kansas, USA

2. Department of Pharmacy, Barnes-Jewish Hospital, St. Louis, Missouri, USA

3. Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

4. Department of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, Missouri, USA

Abstract

Critically ill patients are frequently treated with empirical antibiotic therapy, including vancomycin and β-lactams. Recent evidence suggests an increased risk of acute kidney injury (AKI) in patients who received a combination of vancomycin and piperacillin-tazobactam (VPT) compared with patients who received vancomycin alone or vancomycin in combination with cefepime (VC) or meropenem (VM), but most studies were conducted predominately in the non-critically ill population.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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