Author:
Gardner I D,Remington J S
Abstract
Resistance to infection with Toxoplasma gondii and Listeria monocytogenes in BALB/c female mice decreased with increasing age. The decrease was apparent as early as 9 months of age and was more marked as the animals aged further. This age-related decline in resistance was not restricted to BALB/c female mice, as male and female mice of the C57BL/6 strain exhibited similar responses. With both pathogens, aged mice showed a more marked susceptibility to the strain of lesser virulence. Transfer of normal serum from old mice to young or old mice before infection with T. gondii resulted in an increased susceptibility to this organism, suggesting the presence of inhibitory factors or the absence of potentiating factors that are present in the serum of young mice.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference26 articles.
1. Interactions of antibodies, complement components and various cell types in immunity against viruses and pyogenic bacteria;Allison A. C.;Transplant. Rev.,1974
2. Mechanisms of recovery from a generalized viral infection. II. Passive transfer of recovery mechanisms with immune Iymphoid cells;Blanden R. V.;J. Exp. Med.,1971
3. Decreased resistance to Trichinella spiralis in aged mice;Crandall R. B.;J. Parasitol.,1975
4. Adoptive immunity to intracellular infection;Frenkel J. K.;J. Immunol.,1967
5. Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice;Goidl E. A.;J. Exp. Med.,1976
Cited by
53 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献