Author:
Murphy B R,Harper J,Sly D L,London W T,Miller N T,Webster R G
Abstract
An influenza A virus isolated from seals [A/Seal/Mass/1/80 (H7N7)] and an isolate of this virus obtained from a human conjunctiva were evaluated for replication and virulence in squirrel monkeys. When the seal virus was administered intratracheally, it replicated in lungs and nasopharynges and induced illness almost to the same extent that a human influenza A virus [A/Udorn/72 (H3N2)] did. In one monkey that died of pneumonia, the seal virus was recovered from spleen, liver, and muscle as well as lung. After conjunctival administration in monkeys, the seal virus replicated to a peak titer in the conjunctivae 30-fold greater than that attained by the human virus, but this difference was not statistically significant. In contrast, the seal virus replicated less well than the human virus in the tracheae and nasopharynges when administered by the conjunctival route. These results indicate that the seal virus can replicate efficiently in primates, that it can spread systemically, and that it might differ from human virus in being able to replicate slightly better in primate conjunctival tissue.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference8 articles.
1. Douglas R. G. Jr. 1975. Influenza in man p. 395-447. In E. D. Kilbourne (ed.) The influenza viruses and influenza. Academic Press Inc. New York.
2. Mass mortality of harbor seals: pneumonia associated with influenza A virus;Geraci J. R.;Science,1982
3. Hinshaw V. S. and R. G. Webster. 1982. The natural history of influenza A viruses p. 79-104. In A. S. Beare (ed.) Basic and applied influenza research. CRC Press Boca Raton Fla.
4. Isolation of an influenza A virus from seals;Lang G.;Arch. Virol.,1981
5. Virulence of avian influenza A viruses for squirrel monkeys;Murphy B. R.;Infect. Immun.,1982
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