Infection of Primary Cultures of Human Kupffer Cells by Dengue Virus: No Viral Progeny Synthesis, but Cytokine Production Is Evident-Reference-Cited by-同舟云学术

Infection of Primary Cultures of Human Kupffer Cells by Dengue Virus: No Viral Progeny Synthesis, but Cytokine Production Is Evident

Published:1999-06 Issue:6 Volume:73 Page:5201-5206
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Marianneau Philippe¹,Steffan Anne-Marie²,Royer Cathy²,Drouet Marie-Thérèse¹,Jaeck D.³,Kirn André²,Deubel Vincent¹

Affiliation:

1. Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15,1 and

2. Laboratoire de Virologie de La Faculté de Médecine, INSERM U74,2and

3. Centre de Chirurgie Viscérale et de Transplantation, CHU Hautepierre,3 67000 Strasbourg, France

Abstract

ABSTRACT We investigated the ability of dengue virus to invade human primary Kupffer cells and to complete its life cycle. The virus effectively penetrated Kupffer cells, but the infection did not result in any viral progeny. Dengue virus-replicating Kupffer cells underwent apoptosis and were cleared by phagocytosis. Infected Kupffer cells produced soluble mediators that could intervene in dengue virus pathogenesis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.6.5201-5206.1999

Reference29 articles.

1. Pathology of Thailand haemorrhagic fever: a study of 100 autopsy cases;Bhamarapravati N.;Ann. Trop. Med. Parasitol.,1967

2. Inhibition of vesicular stomatitis virus infection by nitric oxide

3. Couvelard A. P. Marianneau C. Bedel M. T. Drouet F. Vachon D. Hénin and V. Deubel. Report of a fatal case of dengue infection with hepatitis: demonstration of dengue antigens in hepatocytes and liver apoptosis. Human Pathol. in press.

4. Biologically active products of stimulated liver macrophages (Kupffer cells);Decker K.;Eur. J. Biochem.,1990

5. Human isolates of dengue type 1 virus induce apoptosis in mouse neuroblastoma cells

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