Use of frozen native feces for fecal microbiota transplantation in recurrent <i>Clostridioides difficile</i> infection: a simple way to improve the efficiency of donor feces preparation-Reference-Cited by-同舟云学术

Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation

Published:2024-08-21 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sintes Rachel¹²³⁴^ORCID,McLellan Paul²³⁴⁵,Navelli Gabriele¹²³⁴,Landman Cécilia²³⁴⁵,Delage Sandrine¹²³⁴,Truong Sandrine²³⁴⁵,Benech Nicolas⁴⁶,Kapel Nathalie²³⁴⁷,Moreino Sabater Alicia²³⁴⁸,Schnuriger Aurélie²³⁴⁹^ORCID,Eckert Catherine²³⁴¹⁰,Bleibtreu Alexandre²³⁴¹¹,Joly Anne-Christine¹²³⁴,Sokol Harry²³⁴⁵¹²^ORCID

Affiliation:

1. Department of Pharmacy, Sorbonne Université, AP-HP, Saint-Antoine Hospital, Paris, France

2. Assistance Publique-Hopitaux de Paris (AP-HP) FMT Center, Paris, France

3. Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France

4. French Group for Fecal Microbiota Transplantation (GFTF), Paris, France

5. Department of Gastroenterology, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint-Antoine Hospital, Paris, France

6. Department of Hepato-Gastroenterology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

7. Functional Coprology Laboratory, APHP, Pitié Salpêtrière Hospital and Université Paris Cité, INSERM UMRS-1139, Centre d'Immunologie et des Maladies Infectieuses, (CIMI-PARIS), Inserm U1135, Sorbonne Université, Paris, France

8. Sorbonne Université, APHP, National Institute of Health and Medical Research, Center for Immunology and Infectious Diseases-Paris, Saint Antoine Hospital, Parasitology-Mycology, Paris, France

9. Sorbonne Université, AP-HP, Saint-Antoine Hospital, Virology, Paris, France

10. Sorbonne Université, AP-HP, Saint-Antoine Hospital, Bacteriology et Centre d'Immunologie et des Maladies Infectieuses, INSERM, U1135, Sorbonne Université, Paris, France

11. Department of Infectious Disease, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Paris, France

12. Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France

Abstract

ABSTRACT Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent Clostridioides difficile infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% ( P = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.

Funder

Société Nationale Francaise de Gastro Enterologie

Société de Pathologie Infectieuse de Langue Francase

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00734-24

Reference19 articles.

1. Duodenal Infusion of Donor Feces for RecurrentClostridium difficile

2. Fecal Microbiota Transplant for Relapsing Clostridium difficile Infection Using a Frozen Inoculum From Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study

3. Standardized Frozen Preparation for Transplantation of Fecal Microbiota for Recurrent Clostridium difficile Infection

4. Simple faecal preparation and efficacy of frozen inoculum in faecal microbiota transplantation for recurrentClostridium difficileinfection - an observational cohort study