Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians-Reference-Cited by-同舟云学术

Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians

Published:2017-12 Issue:12 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Eloy Philippine¹,Tessier Adrien²,Fan-Havard Patty³⁴,Chou Monidarin⁵,Verstuyft Céline⁶⁷⁸⁹,Taburet Anne-Marie⁷⁹,Haas David W.¹⁰¹¹,Bertrand Julie¹^ORCID

Affiliation:

1. Université Paris Diderot, Sorbonne Paris Cité, Paris, France

2. Division of Clinical Pharmacokinetics and Pharmacometrics, Institut de Recherches Internationales Servier, Suresnes, France

3. School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Amherst, New York, USA

4. College of Medicine, The Ohio State University, Columbus, Ohio, USA

5. Rodolphe Mérieux Laboratory, Faculty of Pharmacy, University of Health Sciences, Phnom Penh, Cambodia

6. Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France

7. INSERM U1184, Le Kremlin-Bicêtre, France

8. Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Hôpital de Bicêtre, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, France

9. Assistance Publique Hôpitaux de Paris, Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, France

10. Vanderbilt University School of Medicine, Departments of Medicine, Pharmacology, Pathology, and Microbiology and Immunology, Nashville, Tennessee, USA

11. Meharry Medical College, Department of Internal Medicine, Nashville, Tennessee, USA

Abstract

ABSTRACT Nevirapine is metabolized by several hepatic cytochrome P450 (CYP) isoforms to generate four primary hydroxylated metabolites: 2-hydroxynevirapine, 3-hydroxynevirapine, 8-hydroxynevirapine, and 12-hydroxynevirapine. The present study characterized associations between genetic polymorphisms and metabolite ratios in HIV-infected Cambodians. We demonstrate associations between CYP2B6 polymorphisms and metabolite ratios for both 3-hydroxynevirapine and 8-hydroxynevirapine, suggesting involvement of CYP2B6 in generating these metabolites.

Funder

Agence Nationale de Recherches sur le Sida et les Hepatites Virales

HHS | NIH | NIH Clinical Center

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00733-17

Reference17 articles.

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3. Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients

4. Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients

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