Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome-Reference-Cited by-同舟云学术

Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome

Published:2015-11 Issue:21 Volume:89 Page:11150-11158
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Seyffert Michael¹,Glauser Daniel L.¹,Tobler Kurt¹,Georgiev Oleg²,Vogel Rebecca¹,Vogt Bernd¹,Agúndez Leticia³,Linden Michael³,Büning Hildegard⁴⁵,Ackermann Mathias¹,Fraefel Cornel¹

Affiliation:

1. Institute of Virology, University of Zurich, Zurich, Switzerland

2. Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

3. Department of Infectious Diseases, King's College London, London, United Kingdom

4. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

5. Institute for Experimental Hematology, Hannover Medical School, Hannover, Germany

Abstract

ABSTRACT Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore, we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/Rep78 to the HSV-1 genome.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01370-15

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