Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis-Reference-Cited by-同舟云学术

Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis

Published:2020-03-23 Issue:4 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lupiañez C. B.¹²³,Martínez-Bueno M.⁴,Sánchez-Maldonado J. M.¹³,Badiola J.²³,Cunha C.⁵⁶,Springer J.⁷,Lackner M.⁸,Segura-Catena J.¹²³,Canet L. M.¹³,Alcazar-Fuoli L.⁹,López-Nevot M. A.¹⁰,Fianchi L.¹¹,Aguado J. M.¹²,Pagano L.¹¹,López-Fernández E.¹²³,Alarcón-Riquelme M.⁴,Potenza L.¹³,Gonçalves S. M.⁵⁶,Luppi M.¹³,Moratalla L.¹²³,Solano C.¹⁴,Sampedro A.³¹⁵,González-Sierra P.¹²³,Cuenca-Estrella M.⁹,Lagrou K.¹⁶¹⁷¹⁸,Maertens J. A.¹⁹,Lass-Flörl C.⁸,Einsele H.⁷,Vazquez L.²⁰,Loeffler J.⁷,Ríos-Tamayo R.¹²³,Carvalho A.⁵⁶,Jurado M.¹²³,Sainz J.¹²³,

Affiliation:

1. Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain

2. Hematology Department, Virgen de las Nieves University Hospital, Granada, Spain

3. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Complejo Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain

4. Genomic Medicine Area, GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain

5. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal

6. ICVS/3B’s, PT Government Associate Laboratory, Braga, Portugal

7. Universitätsklinikum Würzburg, Medizinische Klinik II, Würzburg, Germany

8. Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria

9. Mycology Reference Laboratory, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain

10. Immunology Department, Virgen de las Nieves University Hospital, Granada, Spain

11. Istituto di Ematologia, Università Cattolica del S. Cuore, Rome, Italy

12. Unit of Infectious Diseases, Hospital Universitario “12 de Octubre,” Instituto de Investigación Hospital “12 de Octubre” (i+12), Madrid, Spain

13. Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, Modena, Italy

14. Hematology Department, Hospital Clinico Universitario-INCLIVA, University of Valencia, Spain

15. Department of Microbiology, Virgen de las Nieves University Hospital, Granada, Spain

16. Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

17. Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium

18. National Reference Center for Medical Mycology, University Hospitals Leuven, Leuven, Belgium

19. Department of Hematology, University Hospitals Leuven, Leuven, Belgium

20. Hematology Department, University Hospital of Salamanca, Salamanca, Spain

Abstract

Invasive aspergillosis (IA) is a life-threatening infection that affects an increasing number of patients undergoing chemotherapy or allo-transplantation, and recent studies have shown that genetic factors contribute to disease susceptibility. In this two-stage, population-based, case-control study, we evaluated whether 7 potentially functional single nucleotide polymorphisms (SNPs) within the ARNT2 and CX3CR1 genes influence the risk of IA in high-risk hematological patients.

Funder

Astellas Pharma

ERANET Pathogenomics

The Collaborative Research Center / Transregio 124 Funginet

EC | European Regional Development Fund

MEC | Fundação para a Ciência e a Tecnologia

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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